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"Placenta organoids" may be the future of pregnancy and care care for researchers



Researchers have successfully developed "laboratory" mini placental or placental organoids that can transform pregnancy, conception, mortality, abortion and pregnancy disorders and disorders.

The results of the study on organoid development have been published in the latest issue of the journal Nature.

These organoids successfully mimic the placenta early in the first trimester for researchers. This means that drugs or diseases that have an effect on the placenta at this stage and lead to fetal loss. In fact, these tiny placards are like the real placenta to test the pregnancy test that the team explains. Ashley Moffett, a senior researcher at the University of Cambridge's Reproductive Immunology Team and Professor, confirmed this statement: "If you put a pregnancy stick on the organoids, you're" pregnant. "

The team explains that studying placenta in the uterus was extremely difficult to date. A healthy placenta develops and adheres to the wall of the uterus and nourishes nutrients and oxygenated blood to the growing embryo and the fetus. It selects not only the hormones and chemicals that allow the growth of the fetus, but also the waste generated by the growing fetus. Placentas also select hormones in the maternal blood stream to help the success of pregnancy. These phenomena so far could not be studied in humans. By developing organoids, researchers can get to know the functions and function of the placenta in detail. Moffett said, "We can now begin experiments on how the placenta develops in the bee environment."

The team used cells from the cell of the placenta tissue. These wild are the hairy structure of the normal placenta. These placental cells may be reproduced in laboratory conditions in multiple cell clusters or structures that are capable of secreting proteins and hormones into the true placenta. These sizes range from ten to millimeters to half millimeters and can only be stored freeze-thawed before use.

The reported practitioners welcomed this research and claimed to offer invaluable values ​​for common pregnancy abnormalities, including birth defects, intrauterine growth restriction and pre-eclampsia. Infectious infections such as Zika and their effects on development and growth can also be studied.

Research chief Margherita Turco said in a statement: "Placenta is absolutely necessary to support baby growth inside the mother. If it does not work properly, it can cause serious problems from pre-eclampsia to abortion, with immediate and lifelong consequences both for the mother and for the child. "The group adds that this would be invaluable in testing teratogenic drugs or drugs. may damage the fetus when it is given to the mother. Placenta organoids are also a source of pathogenic therapies during inappropriate or threatened pregnancies. In short, these organoids have multiple applications in pregnancy research.

According to Moffett, "30 years have passed so far, and for at least a year the mini placenta will grow in the laboratory."

Source:

https://www.nature.com/articles/s41586-018-0753-3

Category: Medical Research News | Women's health news

Tags: baby, blood, cells, contraception, drugs, eclampsia, embryo, hair, immunology, lab, abortion, nutrients, organoids, placenta, pre-eclampsia, pregnancy, research, stem cell, obstetrics, bee, bee


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