Moderna vaccine provides at least 3 months of immunity: study


The Moderna vaccine will be reviewed by the Food and Drug Administration (FDA) Advisory Committee on December 17 and may soon turn green for emergency approval.

The Moderna COVID-19 vaccine, which the company says has recently been shown to be 94% effective, produces effective antibodies in the human immune system that last for at least three months.

Researchers at the National Institute for Allergy and Infectious Diseases (NIAID), which is jointly developing the drug, examined the immune responses of 34 adult participants, young and old, from the first phase of the clinical trial.

Writing a New England Journal of Medicine, said antibodies that prevent SARS-CoV-2 virus from entering human cells “decreased slightly over time as expected, but remained high in all participants 3 months after booster vaccination.”

The vaccine, called mRNA-1273, is given in two injections, 28 days apart.

Although the number of antibodies in the subjects has faded over time, this is not necessarily a concern.

According to Anthony Fauci, director of NIAID and other experts, it is very likely that the immune system will remember the virus if it is exposed again later and then produces new antibodies.

Encouragingly, the study showed that the vaccine activated a certain type of immune cell that should help with the so-called memory response, but only a longer-term study confirms that this will indeed be the case.

“The positive results of the study provide evidence that a relatively strong antibody response remains 90 days after the second dose of the vaccine,” said virologist Benjamin Neuman, a virologist at A&M University-Texarkana, Texas.

“The amount of antibodies produced by the vaccine was higher in younger patients than in older patients, but a reasonably strong immune response was seen even before the age of 70 years.”

The Moderna vaccine will be reviewed by the Food and Drug Administration (FDA) Advisory Committee on December 17 and may soon turn green for emergency approval.

Like another vaccine manufactured by Pfizer and BioNTech, it is based on a new technology that uses genetic material in the form of mRNA (messenger ribonucleic acid).

The mRNA is encapsulated in a lipid molecule and injected into the arm, where cells in our muscles build up the coronavirus surface protein.

This tricks the immune system into believing that it is infected with a microbes and teaches it to produce the right type of antibodies in case it encounters the real virus.


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© 2020 AFP

Quote: Moderna vaccine provides at least 3 months of immunity: study (December 3, 2020) downloaded: December 4, 2020, https://medicalxpress.com/news/2020-12-moderna-vaccine-confers-months-immunity.html

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